Graduate Student Seminar

Location

Biological Sciences : 120

Date & Time

April 30, 2014, 11:00 am12:00 pm

Description

First SpeakerIris Gauran
Second Speaker
Session Chair Nilabja Guha
DiscussantDr. Malinovsky
PlaceBS 120
Title
Classification of Congenital Hypothyroidism in Newborn Screening using Self-Organizing Maps
Abstract
Detecting the Congenital Hypothyroidism among neonates is a major concern of medical practitioners because it provides richer information than the healthy cases. However, because of the rarity of this metabolic condition, existing classification algorithms oftentimes misclassify a neonate as “normal.” This paper aims to investigate the efficiency of Self-Organizing Kohonen Maps (SOM)—a type of artificial neural network—as a tool for classification, particularly in detecting outliers. The proposed methodology was able to address the problem of finding a statistical threshold for TSH1 as a reasonable and sound cut-off value. The bootstrap estimate of the standard errors is roughly 5%.