Stat Colloquium [Virtual]: Dr. Getachew Dagne

Title: Does it Matter to Have Study-level or Participant-level Data When Assessing the Effect of Moderation in a Network Meta-analysis?

Abstract:

Meta-analytic methods for combining data from multiple intervention trials are commonly used to estimate the effectiveness of an intervention. They can also be extended to study comparative effectiveness. To do this, a network meta-analysis (NMA) approach is required that combines trials involving direct comparisons within the same trials and indirect comparisons across trials. In this presentation, I’ll talk about extending the existing network methods for main effects to examining moderator effects. In addition, I’ll show how the use of individual participant data (IPD) may increase the sensitivity of NMA for detecting moderator effects, as compared to the traditional NMA that employs study-level effect sizes in a meta-regression framework.